Chitotriosidase gene polymorphisms and mutations limit the determination of chitotriosidase expression in sarcoidosis
نویسندگان
چکیده
منابع مشابه
Chitotriosidase activity in sarcoidosis and some other pulmonary diseases.
BACKGROUND Patients with sarcoidosis have elevated levels of several markers of inflammation. Particularly high levels have been reported for chitotriosidase. In this study, we evaluate whether determining chitotriosidase in serum would be useful in the diagnosis and clinical management of patients with sarcoidosis. METHODS Patients with newly diagnosed sarcoidosis and patients with asthma, f...
متن کاملBronchoalveolar lavage chitotriosidase activity as a biomarker of sarcoidosis.
BACKGROUND Chitotriosidase (CTO) was shown to be a good biomarker of sarcoidosis. Increased levels in bronchoalveolar lavage fluid (BALF) were reported and associated with more severe forms of the disease. OBJECTIVES The aim of the study was to evaluate the value of CTO in BALF as a routine biomarker of sarcoidosis. METHODS The study included 85 patients in 9 control subjects in whom serum ...
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Initial biochemical investigations led to the unexpected discovery that plasma samples of patients with Gaucher disease (GD), a lysosomal storage disease, had a several hundred-fold elevated ability to hydrolyse chitin, a polymer of beta 1,4-linked N-acetylglucosamine that is largely diffuse in nature.1 Later, the same investigators observed that lipid-laden activated macrophages accumulating i...
متن کاملVerifying Sarcoidosis Activity: Chitotriosidase versus ACE in Sarcoidosis – a Case-control Study
BACKGROUND Until now, a proper biomarker(s) to evaluate sarcoidosis activity has not been recognized. The aims of this study were to evaluate the sensitivity and specificity of the two biomarkers of sarcoidosis activity already in use (serum angiotensin converting enzyme - ACE and serum chitotriosidase) in a population of 430 sarcoidosis patients. The activities of these markers were also analy...
متن کاملImmunomodulatory Effects of Chitotriosidase Enzyme
Chitotriosidase enzyme (EC: 3.2.1.14) is the major active chitinase in the human body. It is produced mainly by activated macrophages, in which its expression is regulated by multiple intrinsic and extrinsic signals. Chitotriosidase was confirmed as essential element in the innate immunity against chitin containing organisms such as fungi and protozoa; however, its immunomodulatory effects exte...
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ژورنال
عنوان ژورنال: Clinica Chimica Acta
سال: 2021
ISSN: 0009-8981
DOI: 10.1016/j.cca.2020.11.025